• Most remarkably an essentially identical collagen binding

  2020-11-09

  

  Most remarkably, an essentially identical collagen-binding mode to DDR2 is employed by SPARC, an α-helical matricellular protein unrelated to DDR2 that also recognizes the GVMGFO motif in collagen (Giudici et al., 2008, Hohenester et al., 2008). The convergence of binding mechanisms suggests that th

• In principle in vitro techniques

  2020-11-09

  

  In principle, in vitro techniques for assessing enzyme induction might include the use of cultured hepatocytes, precision-cut liver slices, immortalized AUY922 sale lines (such as those derived from hepatomas) and reporter gene constructs (where appropriate cells are transfected with recombinant DN

• Up to of the host B cells are infected

  2020-11-09

  

  Up to 10% of the host d-glucose sale are infected with EBV during acute infectious mononucleosis. Most of these cells are effectively cleared by the immune system, but some downregulate viral gene expression and differentiate into safety in the resting memory B cell pool. In the persisting infectio

• br RING dimerization RING type

  2020-11-09

  

  RING dimerization RING-type domains are found in many different structural contexts. While many exist as single-chain SBI-0206965 (Fig. 3A), a notable feature of RING-type E3s is their tendency to form homodimers and heterodimers (Fig. 3C–F). Homodimeric RING-type E3s include cIAP, RNF4, BIRC7 (

• Due to the high attractiveness of E and

  2020-11-09

  

  Due to the high attractiveness of E2 and E3 ligases as drug targets, a number of drug discovery assays have been published, based on detection by fluorescence (Dudgeon et al., 2010, Krist et al., 2016, Zhang et al., 2004), Atractyloside Dipotassium Salt receptor (Davydov et al., 2004, Huang et al.,

• According to our results germination

  2020-11-06

  

  According to our results, germination of transgene dgks lines didn’t differ under optimal conditions and 50 mM NaCl, while 100 mM NaCl slightly affected germination rates of dgk mutants. Exogenous application of EBL even diminished the effect of 100 mM NaCl on dgk mutants. The critical effect on ger

• Soluble receptors have been shown to

  2020-11-06

  

  Soluble receptors have been shown to be important and common regulators of many cytokines within the immune system, including IL-1, IL-6, IFNγ, TNF-α, GM-CSF, G-CSF and others (Fernandez-Botran, 1991, Heaney, Golde, 1998). We previously described a novel soluble receptor, sCSF-1R, that to date has o

• Introduction Eicosanoid lipid prostaglandin D PGD is the

  2020-11-06

  

  Introduction Eicosanoid lipid prostaglandin D2 (PGD2) is the major prostaglandin produced by activated mast lipid metabolism (Lewis and Austen, 1981). The physiological function of PGD2 is mainly mediated by two G protein-coupled receptors (GPCRs), PGD2 receptor 1 and 2 (DP1 and DP2), which share

• Preliminary studies evidenced the presence of CRFr in gamma

  2020-11-06

  

  Preliminary studies evidenced the presence of CRFr in gamma-aminobutyric acid-ergic (GABAergic) neurons of the hippocampus (Yan et al., 1998). In fact, in this growth hormone secretagogue area, CRF inhibits glutamate release through CRF1r (Bagosi et al., 2015), leading to a decrease in the GABA conc

• Furthermore collagen could be further utilized to surface mo

  2020-11-06

  

  Furthermore, collagen could be further utilized to surface modification of biologically inert materials, such as polymer materials and metal materials, which are always hydrophobic, lacking functional groups and poor cell adhesion. Therefore, various strategies have been tested to improve the proper

• br Estrogen receptors activate mGluR signaling

  2020-11-06

  

  Estrogen receptors activate mGluR signaling pathways In order to distinguish the opposing effects of estradiol on CREB phosphorylation, we turned to a “bottom-up” approach, working backwards from CREB phosphorylation to pharmacologically isolate the two signaling pathways (Boulware et al., 2005).

• br EphB as a therapeutic target in cancer Eph receptors

  2020-11-06

  

  EphB4 as a therapeutic target in cancer Eph receptors and ephrins are promising new therapeutic targets in cancer. Various strategies have been employed to evaluate the interference of tumor-promoting effects or the enhancement of tumor suppressive effects. The inhibition of the Eph-ephrin system

• Gupta et al have shown that a genetic variant associated

  2020-11-06

  

  Gupta et al have shown that a genetic variant associated with the 5 vascular diseases (coronary artery disease, migraine, carotid artery dissection, fibro-muscular dysplasia, and hypertension) is a distal regulator of the ET-1 gene [30]. They found that a single nucleotide polymorphism (SNP) located

• In addition to through direct regulation of cell differentia

  2020-11-06

  

  In addition to through direct regulation of cell differentiation, DDR2 may raise the abundance of myofibroblast subsets through advancing the recruitment of its precursor cells. One such evidence is that DDR2 can regulate lung fibroblast proliferation and migration. Another possibility rests on the

• br Transparency document br Acknowledgments This work

  2020-11-06

  

  Transparency document Acknowledgments This work was supported by the Ministry of Education, Youth and Sports of the Czech Republic (the National Program of Sustainability I, Grants LO1204 and LO1304), by the Czech Science Foundation (15-17282Y) and by Palacký University Olomouc (IGA_PrF_2017_0

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