• The re treatment of metastatic

  2019-04-30

  

  The re-treatment of metastatic bone disease causing recurrent pain after an initial course of EBRT was seen to be feasible with a reasonable rate of symptom relief [13–19]. In echoing the ACR findings, the task force noted that the available data was derived from studies where re-treatment was not t

• Introduction Dilated phase hypertrophic cardiomyopathy

  2019-04-30

  

  Introduction Dilated-phase hypertrophic cardiomyopathy (DHCM) is a rare subset of hypertrophic cardiomyopathy (HCM) [1]. Data available on sustained monomorphic ventricular tachycardia (SMVT) associated with DHCM is scarce. We report a rare case of SMVT caused by a large epicardial scar related to

• In recent years there has been

  2019-04-29

  

  In recent years, there has been growing interest regarding the role of spliceosome machinery in neoplastic diseases following evidence of the involvement of splicing factor mutations in diverse cancers . (Serine-Arginine Splicing Factor 2) is a member of the serine/arginine (S/A) rich family pre-mR

• The estimated annual burden of injury in rural Bangladesh re

  2019-04-29

  

  The estimated annual burden of injury in rural Bangladesh revealed by this study was striking; 44 050 deaths and 21 million people suffering major injury events annually that were severe enough for them either to be unable to go to work or school for a day, or severe enough for them to seek treatmen

• br The indications for ICD placement for the primary prevent

  2019-04-29

  

  The indications for ICD placement for the primary prevention of sudden cardiac death Guidelines in patients with Brugada syndrome Some investigators [11,12,15,24] have reported that there are no independent predictors in patients without a history of an aborted sudden cardiac death, i.e., ther

• Osteosclerosis was also significant at the level of osteobla

  2019-04-29

  

  Osteosclerosis was also significant at the level of osteoblastic bone metastases. The effect, in this case, seemed to reach a plateau level since the difference between the 24 and the 12 months time point was not significant in this subgroup. Residual osteoclastic activity is present even in sclerot

• By inhibiting osteoclast activity one possible option relies

  2019-04-29

  

  By inhibiting osteoclast activity, one possible option relies to bisphosphonates, the synthetic analogs of pyrophosphate that induce osteoclast apoptosis, decrease osteoclast activation and function by inhibition of the mevalonate pathway [32]. Such therapeutic tools have been studied in primary bon

• Loss of function mutations in the

  2019-04-29

  

  Loss-of-function mutations in the INa channel α-subunit (SCN5A) is the most common (~20%) etiology of BrS [49]. Recently, SCN10A, a neuronal sodium channel gene encoding Nav1.8 has been identified as a major susceptibility gene (~16%) for BrS [50]. In addition, loss-of-function mutations in the ICa,

• Although SCN A variants account for of

  2019-04-29

  

  Although SCN5A variants account for 18–28% of BrS [196], SCN5A genetic testing is complicated by an approximately 3–5% “benign” variant frequency in the general population [194]. Therefore, even in the most common genetic cause of BrS, 1 in 10 “positive” tests could be a “false- positive” even if fo

• Introduction Pulmonary vein isolation PVI is an established

  2019-04-29

  

  Introduction Pulmonary vein isolation (PVI) is an established strategy of paroxysmal atrial fibrillation (PAF) ablation [1–3]. Radiofrequency catheters have been the standard for AF ablation; however, PVI using balloon-based ablation has been increasingly adopted by electrophysiology laboratories a

• Un recurso semejante al empleado por Eloy

  2019-04-29

  

  Un recurso semejante al empleado por Eloy Martínez lo podemos encontrar en Agosto. Una vez que los implicados en el asesinato del edificio Deauville reconocen que Mattos se les acerca peligrosamente, deciden eliminar el único punto frágil de su coartada: el portero (Raimundo) del edificio, de quien

• Patient a year old man with RAEB and severe chronic

  2019-04-29

  

  Patient 2, a 54-year-old man with RAEB 2, and severe chronic obstructive pulmonary disease, struggled through induction chemotherapy with daunorubicin plus cytarabine (DA) 3+10. Second DA 3+8 produced delayed hematopoietic recovery. CR1 was documented after course 1 and lasted 18 months. Relapse was

• br Conflict of interests br Chronic lymphocytic leukemia CLL

  2019-04-29

  

  Conflict of interests Chronic lymphocytic leukemia (CLL) is the most frequent hematologic neoplasm in Western countries. The clinical course of chronic lymphocytic leukemia ranges from a very indolent disorder with a normal lifespan, to a rapidly progressive disease leading to death. The variab

• br Conflict of interest br Authorship contributions br

  2019-04-29

  

  Conflict of interest Authorship contributions Introduction Clofarabine, a purine nucleoside analog of cladribine, is used in adult and pediatric regimens to treat Acute Myeloid Leukemia (AML) and Acute Lymphoblastic Leukemia (ALL). Use of clofarabine has been studied as monotherapy [1] and

• br Materials and methods br Results br Discussion Interest i

  2019-04-28

  

  Materials and methods Results Discussion Interest in phenolic compounds has grown over the last several decades owing to the recognition of their antioxidant properties and their probable role in the prevention of a number of pathologies associated with oxidative stress [23]. Taking into ac

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