• br DAG kinase activity is confined

  2021-01-11

  

  DAG kinase activity is confined to specific cell compartments A number of reports demonstrating agonist-dependent translocation of DGKs to distinct membrane compartments suggest that DGK activity is restricted to localized DAG pools generated after activation of receptors. Perhaps the best eviden

• Inhibition of DHODH is reflected by an

  2021-01-11

  

  Inhibition of DHODH is reflected by an antiproliferative effect on peripheral blood mononuclear knowledge (PBMCs), which can be measured by the inhibitory effect on their phytohemagglutinin (PHA) stimulated growth. The test was performed as described in the reference. Data for few selected compound

• Aldehyde dehydrogenase has been characterized as a

  2021-01-11

  

  Aldehyde dehydrogenase has been characterized as a cancer stem cell marker, which plays a key role in various biological processes in tumor, including cell proliferation, invasiveness and chemoresistance. Recent data of Abourbih et al reported that ALDH1 expression did not correlate with primary tum

• br Conclusions Overexpression of DDR might contribute

  2021-01-11

  

  Conclusions Overexpression of DDR2 might contribute to tumor progression in lung SQCC, and the T681I mutation we found in this work is an inactivating mutation. There is a possibility that not only activating mutation but also overexpression of DDR2 might be a molecular target for treatment of lu

• Henderson et al reported that allergen

  2021-01-11

  

  Henderson et al. [20] reported that allergen-induced airway remodeling was blocked by the CysLT1 receptor antagonist montelukast. The development of epithelial thickening and mucus accumulation at relatively small bronchi was also suppressed by montelukast. The CysLT2 receptor antagonist BayCysLT2RA

• CYP s are heme containing monooxygenases constituting a cons

  2021-01-11

  

  CYP450s are heme-containing monooxygenases constituting a conserved gene superfamily of heme-thiolate proteins, and are found in prokaryotes and eukaryotes (Martignoni et al., 2006). They play a key role in detoxification of endogenous (e.g., steroids) and exogenous compounds (e.g., drug, insecticid

• As previously reported azole class antifungal drugs inhibit

  2021-01-11

  

  As previously reported, azole class antifungal drugs inhibit fungal CYP450 14α-demethylase, as this interrupts the conversion of lanosterol to ergosterol, a component of the fungal cell membrane (Hof, 2006). Furthermore, correlation between fluconazole dose, the extent of hepatic hypertrophy, the le

• To elucidate the potential mechanism underlying

  2021-01-11

  

  To elucidate the potential mechanism underlying osteosarcoma cell growth decrease by CDK4 inhibition, flow cytometry analysis was used to determine neurokinin receptor antagonist and apoptosis in human osteosarcoma cells after palbociclib treatment. The results showed that osteosarcoma cells were a

• Fluticasone propionate synthesis Tumor associated macrophage

  2021-01-11

  

  Tumor-associated macrophages (TAMs)—one of the limiting factors in anti-tumor immunity—are associated with the poor clinical outcome in most carcinomas, owing to their potential to promote angiogenesis and local invasion, increase the metastasis of tumor cells, and inhibit the anti-tumor immunity.11

• br Methods br Results br Discussion The lowest

  2021-01-11

  

  Methods Results Discussion The lowest intra-CeA dose of R278995/CRA0450 that prevented the elevations in AR-12 reward thresholds associated with nicotine withdrawal was 0.05μg/side (0.1μg total bilateral dose). The total bilateral dose in the present study is 100 times lower than the lowes

• Social memory is encoded within certain sites but meaning

  2021-01-11

  

  Social memory is encoded within certain sites, but meaning depends upon an interpretant (such as a tourist) being able to decode the signs. Memorials, such as cemeteries, require some kind of activity by its visitors for their meanings to be activated (Hutchinson, 2009, Winter, 2010). Following Eden

• Previous studies have documented that SCFAs may

  2021-01-11

  

  Previous studies have documented that SCFAs may elicit effects on lipid metabolism via de novo synthesis and transport. Acetate is not only used as an energy source, but is also constituted as a substrate for the cholesterol synthesis in the liver through acetyl-CoA, thus affecting plasma cholestero

• In the previous study glutamyl endopeptidase of B intermediu

  2021-01-11

  

  In the previous study glutamyl endopeptidase of B. intermedius has been reported to be distributed in the TOK-001 of B. intermedius as follows: 90% of synthesized enzyme has been detected in the culture liquid, 9.3% of glutamyl endopeptidase—in the fraction of membrane proteins [20]. The distributi

• Nexturastat A Emphysema is an important component of COPD

  2021-01-11

  

  Emphysema is an important component of COPD, which is responsible for airflow limitation. In the present study, a significant airspace enlargement was observed 21 days after elastase administration. Interestingly, daily administration of olaparib provided greater protection against emphysema as comp

• p as a cyclin dependent kinase inhibitor

  2021-01-09

  

  p21, as a cyclin-dependent kinase inhibitor, exert significant negative regulator of proliferation, and it could be transcriptional upregulated by p53 in order to impel transient Aminoallyl-UTP arrest (Romanov et al., 2010). Using western blotting, we found that the protein expression of p21 upgrade

15280 records 701/1019 page Previous Next First page 上5页 701702703704705 下5页 Last page